LAILI, AENA (2020) VALIDASI METODE SPEKTROFOTOMETRI UV-Vis PADA PENETAPAN KADAR DAN STABILITAS AMBROXOL HCl DALAM 3 MERK SEDIAAN SIRUP TERHADAP LAMA DAN SUHU PENYIMPANAN. Undergraduate thesis, Stikes Karya Putra Bangsa Tulungagung.
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Abstract
Ambroxol HCl syrup is a cough therapy that children's patients often use. The preparation of syrup is stored in tightly sealed containers and in a cool place or at room temperature to be stable. The stability of the syrup should be observed at the time of storage, so that there is no degradation affected by time and storage temperature. So it needs to be done research related to old influences and storage temperature of syrup to levels and stability. Determination of the levels of Ambroxol HCl in syrup using UV-Vis spectrophotometry method. Research is conducted to know the methods used to meet the requirements of validation parameters include accuracy, precision, linearity, LOD and LOQ as well as to determine the content and stability of syrup in storage. The result of a wavelength optimization of 200nm. The results of the linearity test with the regression equation y = 0, 034x + 0.0528, have a correlation coefficient (R2) of 0.9808. Accuracy test result (% recovery) 95.702% and precision (RSD) 1.210%. LOD results 9.217 ppm and LOQ 30,723 ppm. The determination of the rate is done based on the length of storage measured by one week in 3 weeks (0, 1st, 2nd and 3rd week) of syrup stored in room temperature (< 30 º C) and cooling cupboard temperature (2-8 º C). The results obtained during storage and at the specified temperature experienced a steady decrease in levels with the significance value obtained < 0.05, so that the H0 is acceptable which means there is no old influence and storage temperature against the level of Ambroxol HCl in the syrup. The stability test of the Ambroxol HCl syrup by conducting organoleptical tests, pH tests, and clarity tests. Organoleptic test results show that all samples have the same shape, smell, color and flavor as the syrup is opened, as well as the clarity test results indicate a clear solution. Based on the pH syrup test has pH 6 and 5. Can be deduced UV-Vis spectrophotometry method for determination of Ambroxol HCl levels meet the requirements of the validation parameters and content of Ambroxol HCl Experienced a steady decline and physical stability that meets the requirements of Depkes RI (1995). Keywords: Ambroxol HCl, method validation, determination of content, duration and storage temperature, stability
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | Ambroxol HCl, validasi metode, penentuan kadar, lama dan suhu penyimpanan, stabilitas |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry R Medicine > R Medicine (General) |
| Divisions: | Program Studi > S1 Farmasi |
| Depositing User: | Surya Hadi Prasetyo |
| Date Deposited: | 23 May 2022 04:24 |
| Last Modified: | 23 May 2022 04:24 |
| URI: | http://repository.stikes-kartrasa.ac.id/id/eprint/67 |
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