RACHUTAMI, IKA (2021) UJI AKTIVITAS ANTIKANKER EKSTRAK ETANOL DAUN JINTEN (Plectranthus Amboinicus) TERHADAP Artemia Salina LEACH DENGAN METODE BST (Brine Shrimp Lethality Test). Undergraduate thesis, Stikes Karya Putra Bangsa Tulungagung.
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Abstract
Cancer is one of the leading causes of death worldwide. There are many treatments done for cancer such as chemotherapy, radiation to traditional coronation such as the use of cumin plants. Cumin plant is a plant that is toxic to cancer cells, it can be seen from existing studies, especially on the part of cumin seeds. however, other parts of the cumin plant also have the same potential, but not so much researched as in the cumin seed section. The purpose of this study is to determine the content and levels of secondary metabolite compounds that have anticancer activity in cumin leaf ethanol extract using UV-Vis spectrophotometers, and to determine the level of acute toxicity (LC50) contained in cumin leaf ethanol extract against artemia salina LEACH larvae by BST method. In this study using experimental methods. Cumin leaf extract is obtained by maceration using ethanol 96%, which is then tested qualitatively and quantitatively. Testing the toxicity of cumin leaf extract using concentrations of 500ppm, 1000ppm, 1500ppm, 2000ppm and 2500ppm administered to artemia salina leach larvae for 24 hours and calculating LC50 values using probit analysis. Qualitative and quantitative testing results of cumin leaf extract contain flavonoid compounds of 23.925%, tannin compounds by 8.208%, saponin compounds by 5.196%, and alkaloid compounds by 4.371%. Meanwhile, from the results of acute toxicity test of cumin leaf ethanol extract (Plectranthus Amboinicus) using Brine Shrimp Lethality Test (BST) method resulted in LC50 value of 697.99ppm. From the lc50 value obtained it can be concluded that cumin leaf ethanol extract (Plectranthus Amboinicus) has toxic properties to larvae and potentially as an anticancer with marked lc50 value acquisition < 1000ppm. Keywords: Anticancer, LC50, Cumin Leaves, BST Method
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | Antikanker, LC50 , Daun Jinten, Metode BST |
| Subjects: | Q Science > Q Science (General) Q Science > QK Botany R Medicine > R Medicine (General) |
| Divisions: | Program Studi > S1 Farmasi |
| Depositing User: | Surya Hadi Prasetyo |
| Date Deposited: | 10 Jun 2022 03:18 |
| Last Modified: | 10 Jun 2022 03:18 |
| URI: | http://repository.stikes-kartrasa.ac.id/id/eprint/98 |
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