Antibacterial Activity of Ethyl Acetate Extract and Cream Formulation of Coleus atropurpureus Leaves against Staphyloccous aureus

Tarigan, Indra lasmana and Muadifah, Afidatul and Nindita clourisa amaris, Susanto and Huda, Choirul (2021) Antibacterial Activity of Ethyl Acetate Extract and Cream Formulation of Coleus atropurpureus Leaves against Staphyloccous aureus. PHARMACEUTICAL JOURNAL OF INDONESIA, 7 (1). pp. 1-8. ISSN 2461-114X

Text jurnal Afi-PJI desember 2021.pdf Download (268kB)

Abstract

Introduction: The major cause of numerous infections in both communities and healthcare facilities is Staphylococcus aureus (Sa). Sa can attack and survive in epithelial cells including endothelial cells and is increasingly showing resistance to multiple antimicrobial agents. Attempts to overcome the infection caused by Sa by giving antibiotics, which work as antibacterial. Myana (Coleus atropurpureus L. Benth) leaves contain several active compounds that might act as antibacterial agents. Objectives: This study aimed to analyze the antibacterial activity of Coleus extract and evaluate the formulation of the extract cream against the bacteria causing infection, Sa. Methods: Coleus leaves ethyl acetate extract contains alkaloids and tannins. Our cream formulation with criteria: the pH value, homogeneity, spreadability, adhesion, and protection power. Our cream formulation results were then evaluated based on the standard, with criteria: the pH value, homogeneity, spreadability, adhesion, and protection power. Results: The absorbance of Sa at the 3rd hour was getting smaller, from 0.668 to 0.552, this showed that the longer the incubation time of the extract against bacterial inoculation, the more bacteria died. It seems that our cream is per the cream standards. It is semi-solid, brownish-white in color, smells typical of Coleus, and pH 6. Moreover, the cream is homogeneous with 5 cm of spreadability, 7 seconds for adhesion, and colorless. Conclusions: Coleus extract cream has better antibacterial activity than positive control with a wound closure time of 7-14 days for extract while more than 14 days for positive control. Keyword : Coleus leaves, antibacterial activity, cream formulation.

Item Type:	Article
Subjects:	Q Science > QD Chemistry Q Science > QK Botany R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Program Studi > S1 Farmasi
Depositing User:	Surya Hadi Prasetyo
Date Deposited:	05 Jan 2022 04:17
Last Modified:	10 Jan 2022 02:38
URI:	http://repository.stikes-kartrasa.ac.id/id/eprint/5

Actions (login required)

View Item